GABA: Benefits, Dosage & Research
Gamma-Aminobutyric Acid, the brain's primary inhibitory neurotransmitter. Supplemental GABA promotes relaxation and reduces neural excitability, though debate exists about its ability to cross the blood-brain barrier.
Source
Naturally produced in the brain from glutamate via the enzyme GAD (glutamic acid decarboxylase). Supplemental GABA is produced through fermentation. PharmaGABA (naturally fermented) may have better efficacy than synthetic.
Researched Benefits
- Promotes relaxation and reduces nervous tension
- May improve sleep onset and quality
- Supports a calm mental state during stress
- May reduce blood pressure in mildly hypertensive individuals
Dosage & Protocol
100-750mg daily. 100-200mg of PharmaGABA for mild calming; 500-750mg of standard GABA for stronger effect. Can be taken as needed or before bed.
Safety & Interactions
Generally safe. May cause drowsiness at higher doses -- do not drive or operate machinery until you know your response. May interact with anti-anxiety medications and antihypertensives. Not recommended during pregnancy or breastfeeding.
